DNA Replication Pathway

Preferred Label : DNA Replication Pathway;

NCIt related terms : DNA replication;

Alternative definition : KEGG: A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.;

KEGG ID : hsa03030;

Details

Origin ID

C91448;

UMLS CUI

C2984261;

Automatic exact mappings (from CISMeF team)
- DNA replication [MeSH concept]
- DNA replication [GO term]
- DNA replication [OBI concept]
- Deoxyribonucleic acid replication (finding) [SNOMED CT concept]
- dna replication [MeSH Descriptor]
- dna replication [SNOMED Notion]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]
- DNA Polymerase Epsilon Catalytic Subunit A [NCIt concept]
- DNA Polymerase Epsilon Subunit 2 [NCIt concept]
- DNA Primase Large Subunit [NCIt concept]
- DNA Primase Small Subunit [NCIt concept]
- DNA Replication ATP-Dependent Helicase/Nuclease DNA2 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Replication Factor C Subunit 1 [NCIt concept]
- Replication Factor C Subunit 2 [NCIt concept]
- Replication Factor C Subunit 3 [NCIt concept]
- Replication Factor C Subunit 4 [NCIt concept]
- Replication Factor C Subunit 5 [NCIt concept]
- Replication Protein A 14 kDa [NCIt concept]
- Replication Protein A 32 kDa Subunit [NCIt concept]
- Replication Protein A 70 kDa DNA-Binding Subunit [NCIt concept]
- Ribonuclease H2 Subunit B [NCIt concept]
- Single-Stranded DNA-Binding Protein, Mitochondrial [NCIt concept]
pathway_has_gene_element
- DNA2 wt Allele [NCIt concept]
- FEN1 wt Allele [NCIt concept]
- POLD1 wt Allele [NCIt concept]
- POLD3 wt Allele [NCIt concept]
- POLE wt Allele [NCIt concept]
- POLE2 wt Allele [NCIt concept]
- PRIM1 wt Allele [NCIt concept]
- PRIM2 wt Allele [NCIt concept]
- RFC1 wt Allele [NCIt concept]
- RFC2 wt Allele [NCIt concept]
- RFC3 wt Allele [NCIt concept]
- RFC4 wt Allele [NCIt concept]
- RFC5 wt Allele [NCIt concept]
- RNASEH2B wt Allele [NCIt concept]
- RPA1 wt Allele [NCIt concept]
- RPA2 wt Allele [NCIt concept]
- RPA3 wt Allele [NCIt concept]
- SSBP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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