Cytosolic 5'-Nucleotidase 1A

Preferred Label : Cytosolic 5'-Nucleotidase 1A;

NCIt synonyms : EC 3.1.3.99; cN1A; EC 3.1.3.5; Cytosolic 5'-Nucleotidase IA; cN-I; 5'-Deoxynucleotidase; EC 3.1.3.89; cN-IA; NT5C1A;

NCIt related terms : cN-1A; Mup44;

NCIt definition : Cytosolic 5'-nucleotidase 1A (368 aa, 41 kDa) is encoded by the human NT5C1A gene. This protein plays a role in the hydrolysis of ribonucleoside and deoxyribonucleoside monophosphates.;

Alternative definition : CDISC: An antigen encoded by the NT5C1A gene and is involved in the dephosphorylation of nucleotides to nucleosides. It can be considered as an autoantigen and is commonly associated with autoimmune disease sporadic inclusion body myositis.;

NCIt note : Cytosolic 5'-nucleotidase 1A preferentially catalyzes the removal of the phosphate group from AMP, dCMP and IMP. (UniProt);

Details

Origin ID

C201947;

OMIM relation
- 5-prime-nucleotidase, cytosolic, ia [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- NT5C1A Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Skeletal Muscle Cell [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_chemical_classification
- 5' Nucleotidase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Nicotinate and Nicotinamide Metabolism Pathway [NCIt concept]
- Nucleotide Metabolism Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]

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