Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3

Preferred Label : Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3;

NCIt synonyms : Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3; SIP-110; s-SHIP; Truncated INPP5D; Short-SHIP;

NCIt definition : Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3 (976 aa, 109 kDa) is encoded by the human INPP5D gene. This protein plays a role in the removal of phosphate from phosphatidylinositol trisphosphate and may play a role in stem cell maintenance.;

NCIt note : The mRNA encoding phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3 is transcribed from an internal promoter and is lacking an SH2 domain. (Stem Cells Dev. 2006;15:641-6.);

PubMed : 17105399;

Details

Origin ID

C104986;

UMLS CUI

C3641901;

Automatic exact mappings (from CISMeF team)
- nevus [MeSH Descriptor]
OMIM relation
- Inositol polyphosphate-5-phosphatase, 145-kd [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- INPP5D Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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