Protein Tyrosine Phosphatase Type IVA 3

Preferred Label : Protein Tyrosine Phosphatase Type IVA 3;

NCIt synonyms : Protein-Tyrosine Phosphatase of Regenerating Liver 3; PRL-R; PRL-3; Potentially Prenylated Protein Tyrosine Phosphatase; Phosphatase of Regenerating Liver 3; EC 3.1.3.48; PTP4A3; Protein-Tyrosine Phosphatase 4a3;

NCIt definition : Protein tyrosine phosphatase type IVA 3 (173 aa, 20 kDa) is encoded by the human PTP4A3 gene. This protein plays a role in tyrosine phosphatase activity that promotes cell cycle progression.;

NCIt note : Protein tyrosine phosphatase type IVA 3 is farnesylated, which localizes its phosphatase activity to the interior face of the plasma membrane.;

NCI Metathesaurus CUI : CL553238;

Details

Origin ID

C151406;

UMLS CUI

C1436378;

Automatic exact mappings (from CISMeF team)
- Prolactin receptor [OMIM gene]
- Protein-tyrosine phosphatase, type 4a, 3 [OMIM gene]
- Submaxillary gland androgen-regulated protein 3b [OMIM gene]
- prolactin receptor [ORDO Gene]
- protein tyrosine phosphatase 4A3 [HGNC gene]
OMIM relation
- Protein-tyrosine phosphatase, type 4a, 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTP4A3 protein, human [MeSH Supplementary Concept]
- PTP4A3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTP4A3 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- PTP4A Family Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Migration Induction [NCIt concept]
- Cell Proliferation [NCIt concept]
- Dephosphorylation [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-PRL-3 Monoclonal Antibody PRL3-zumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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