GDH/6PGL Endoplasmic Bifunctional Protein

Preferred Label : GDH/6PGL Endoplasmic Bifunctional Protein;

NCIt synonyms : H6PD; Hexose-6-Phosphate Dehydrogenase/6-Phosphogluconolactonase;

NCIt definition : GDH/6PGL endoplasmic bifunctional protein (791 aa, 89 kDa) is encoded by the human H6PD gene. This protein is involved in the first two steps of the oxidative branch of the pentose phosphate shunt.;

NCIt note : GDH/6PGL endoplasmic bifunctional protein exhibits two types of enzymatic activity: hexose-6-phosphate dehydrogenase (GDH; EC 1.1.1.47) and 6-phosphogluconolactonase (6PGL; EC 3.1.1.31). (UniProt);

NCI Metathesaurus CUI : CL1799191;

Détails

Origin ID

C190509;

UMLS CUI

C5780718;

Automatic exact mappings (from CISMeF team)
- Hexose-6-phosphate dehydrogenase [OMIM gene]
- hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [ORDO Gene]
- hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [HGNC gene]
OMIM relation
- Hexose-6-phosphate dehydrogenase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- H6PD Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Oxidative Reactions of the Pentose Phosphate Pathway [NCIt concept]
- Pentose Phosphate Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Carbohydrate Metabolic Process [NCIt concept]
- Energy Metabolism Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

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