Phosphatidylcholine-Sterol Acyltransferase

Preferred Label : Phosphatidylcholine-Sterol Acyltransferase;

NCIt synonyms : Lecithin-Cholesterol Acyltransferase; 1-Alkyl-2-Acetylglycerophosphocholine Esterase; Testicular Secretory Protein Li 24; Phospholipid-Cholesterol Acyltransferase; PAF Acetylhydrolase; LCAT; Platelet-Activating Factor Acetylhydrolase;

NCIt definition : Phosphatidylcholine-sterol acyltransferase (440 aa, 50 kDa) is encoded by the human LCAT gene. This protein plays a role in the conversion of cholesterol and phosphatidylcholines to cholesteryl esters and lysophosphatidylcholines.;

NCIt note : Phosphatidylcholine-sterol acyltransferase has activities that correspond to EC 2.3.1.43 and EC 3.1.1.47. (UniProt);

NCI Metathesaurus CUI : CL964442;

Détails

Origin ID

C202874;

UMLS CUI

C4743186;

OMIM relation
- Lecithin:cholesterol acyltransferase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- LCAT protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- LCAT Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycerophospholipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Hydrolysis [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

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