Class II AP Endonuclease

Preferred Label : Class II AP Endonuclease;

NCIt synonyms : Class-II AP-Endonuclease;

NCIt definition : Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. (From LocusLink 27301);

Details

Origin ID

C21422;

UMLS CUI

C1333055;

Biochemical function of gene products
- N-Glycosylase/DNA Lyase [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Lyase Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Hydrolysis [NCIt concept]

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