6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

Preferred Label : 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3;

NCIt synonyms : Renal Carcinoma Antigen NY-REN-56; 6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; iPFK-2; 6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme; PFKFB3;

NCIt definition : 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (520 aa, 60 kDa) is encoded by the human PFKFB3 gene. This protein plays a role in the metabolism of fructose.;

NCIt note : 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 has the functionality of both 6-phosphofructo-2-kinase (EC 2.7.1.105) and fructose-2,6-bisphosphatase (EC 3.1.3.46). (UniProt);

Details

Origin ID

C102810;

UMLS CUI

C3539535;

OMIM relation
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PFKFB3 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Phosphofructokinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Fructose and Mannose Metabolism Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Dephosphorylation [NCIt concept]
- Glycolysis [NCIt concept]
- Hydrolysis [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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