Cocaine Esterase

Preferred Label : Cocaine Esterase;

NCIt synonyms : hCE-2; EC 3.1.1.56; EC 3.1.1.1; Carboxylesterase 2; Intestinal Carboxylesterase; CE-2; Liver Carboxylesterase-2; Methylumbelliferyl-Acetate Deacetylase 2; CES2;

NCIt definition : Cocaine esterase (559 aa, 62 kDa) is encoded by the human CES2 gene. This protein is involved in drug catabolism.;

NCIt note : Substrates for cocaine esterase include: cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. (UniProt);

Détails

Origin ID

C116039;

UMLS CUI

C1869509;

Automatic exact mappings (from CISMeF team)
- Carboxylesterase (substance) [SNOMED CT concept]
- Carboxylesterase 1 [OMIM gene]
- Carboxylesterase 1 [OMIM Phenotype]
- Carboxylesterase 2 [OMIM gene]
- carboxylesterase 2 [HGNC gene]
- cocaine esterase [MeSH concept]
- cocaine esterase [MeSH Supplementary Concept]
OMIM relation
- Carboxylesterase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CES2 protein, human [MeSH Supplementary Concept]
- CES2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CES2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hepatic Tissue [NCIt concept]
- Intestinal Wall Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Carboxylesterase [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

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