Carboxylesterase 1

Preferred Label : Carboxylesterase 1;

Symbol : CES1;

CISMeF acronym : CEH; CES2; CES1;

Type : Gene and phenotype, combined;

Alternative titles and symbols : Serine esterase 1; Carboxylesterase, liver; Triacylglycerol hydrolase; Carboxylesterase 2; Cholesterol ester hydrolase, neutral, macrophage-derived; SES1; TGH; CES2; CEH;

Included titles and symbols : Monocyte esterase deficiency; Monocyte carboxylesterase deficiency; Carboxylesterase 1 deficiency;

Description : Mammalian liver carboxylesterases (CESs; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals (Satoh, 1987). CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux Ghosh and Natarajan (2001).;

Inheritance : Autosomal dominant;

Prefixed ID : 114835;

Details

Origin ID

114835;

UMLS CUI

C1413347;

Automatic exact mappings (from CISMeF team)
- CES1 Gene [NCIt concept]
- CES1 gene [LOINC component]
- CES1 wt Allele [NCIt concept]
- CES2 Gene [NCIt concept]
- Cocaine Esterase [NCIt concept]
- Liver Carboxylesterase 1 [NCIt concept]
- carboxylesterase 1 [HGNC gene]
- carboxylesterase 2 [HGNC gene]
- monocyte carboxylesterase deficiency [MeSH concept]
- monocyte esterase deficiency [MeSH concept]
- monocyte esterase deficiency [MeSH Supplementary Concept]
False automatic mappings
- lipase [MeSH Descriptor]
- lipase [MeSH concept]
Manual NTBT mappings (CISMeF)
- carboxylesterase 1 deficiency [Disease (Nov.)]
NCIt concept(s)
- CES1 Gene [NCIt concept]
- CES1 wt Allele [NCIt concept]
- Liver Carboxylesterase 1 [NCIt concept]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- CES1 Gene [NCIt concept]
- CES1 gene [LOINC component]
- carboxylesterase 1 [HGNC gene]

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