Liver Carboxylesterase 1

Preferred Label : Liver Carboxylesterase 1;

NCIt synonyms : Acyl-Coenzyme A:Cholesterol Acyltransferase; hCE-1; Triacylglycerol Hydrolase; Cocaine Carboxylesterase; TGH; REH; EC 3.1.1.56; EC 3.1.1.1; Human Monocyte/Macrophage Serine Esterase 1; Monocyte/Macrophage Serine Esterase; Brain Carboxylesterase HBr1; CE-1; Egasyn; Serine Esterase 1; ACAT; HMSE; Acyl Coenzyme A:Cholesterol Acyltransferase; Retinyl Ester Hydrolase; Methylumbelliferyl-Acetate Deacetylase 1; CES1;

NCIt definition : Liver carboxylesterase 1 (567 aa, 63 kDa) is encoded by the human CES1 gene. This protein plays a role in the catabolism of drugs and aromatic and aliphatic esters.;

NCIt note : Substrates for liver carboxylesterase 1 include: cocaine, ethanol, 4-methylumbelliferyl acetate, 6-monoacetylmorphine, oleic acid and D- and L-methylphenidate. (UniProt and EntrezGene);

Details

Origin ID

C116036;

UMLS CUI

C1258847;

Automatic exact mappings (from CISMeF team)
- Acetyl-coa acetyltransferase 1 [OMIM gene]
- Carboxylesterase 1 [OMIM Phenotype]
- Carboxylesterase 1 [OMIM gene]
- Egasyn [OMIM Phenotype]
- Rna guanylyltransferase and 5-prime-phosphatase [OMIM gene]
- acetyl-CoA acetyltransferase 1 [ORDO Gene]
- carboxylesterase 1 [HGNC gene]
- cocaine esterase [MeSH Supplementary Concept]
- cough [MeSH Descriptor]
- egasyn [MeSH Supplementary Concept]
- egasyn [MeSH concept]
- lipase [MeSH Descriptor]
- retinyl esterase [MeSH Supplementary Concept]
OMIM relation
- Carboxylesterase 1 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CES1 protein, human [MeSH Supplementary Concept]
- CES1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CES1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hepatic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Carboxylesterase [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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