Receptor-Type Tyrosine-Protein Phosphatase T

Preferred Label : Receptor-Type Tyrosine-Protein Phosphatase T;

NCIt synonyms : Receptor Type Protein Tyrosine Phosphatase T; RPTP Rho; R-PTP-T; PTPRT; Protein Tyrosine Phosphatase Receptor Type-T; EC 3.1.3.48; Receptor-Type Tyrosine-Protein Phosphatase Rho;

NCIt definition : Receptor-type tyrosine-protein phosphatase T (1441 aa, 162 kDa) is encoded by the human PTPRT gene. This protein is involved in cell-cell adhesion, signal transduction and protein dephosphorylation.;

NCIt note : Receptor-type tyrosine-protein phosphatase T is a receptor-type PTP with an extracellular region containing 4 fibronectin type III domains, 1 Ig-like C2-type domain, and 1 MAM domain; a single transmembrane region; and 2 tandem intracellular PTP catalytic domains. PTPRT may be involved in signal transduction and cellular adhesion in the CNS.;

Details

Origin ID

C37315;

UMLS CUI

C0761615;

Currated CISMeF NLP mapping
- protein tyrosine phosphatase, receptor type T [MeSH concept]
OMIM relation
- Protein-tyrosine phosphatase, receptor-type, t [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPRT protein, human [MeSH concept]
- PTPRT protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PTPRT Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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