Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1

Preferred Label : Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1;

NCIt synonyms : Phosphodiesterase I/Nucleotide Pyrophosphatase 1; Plasma-Cell Membrane Glycoprotein 1; Ectonucleotide Pyrophosphatase/Phosphodiesterase 1; Plasma-Cell Membrane Glycoprotein PC-1; Membrane Component Chromosome 6 Surface Marker 1; ENPP1; Ly-41 Antigen;

NCIt definition : Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (925 aa, 105 kDa) is encoded by the human ENPP1 gene. This protein plays a role in the cleavage of phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars.;

NCIt note : A secreted form of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is produced intracellularly by cleavage at Lys-103. The secreted form has the following activities: alkaline phosphodiesterase I (EC:3.1.4.11) and nucleotide pyrophosphatase (EC:3.6.1.91; NPPase; nucleotide diphosphatase). (UniProt);

Details

Origin ID

C187094;

UMLS CUI

C1617587;

Automatic exact mappings (from CISMeF team)
- Ectonucleotide pyrophosphatase/phosphodiesterase 1 [OMIM gene]
- ectonucleotide pyrophosphatase phosphodiesterase 1 [MeSH Supplementary Concept]
- ectonucleotide pyrophosphatase phosphodiesterase 1 [MeSH concept]
- ectonucleotide pyrophosphatase/phosphodiesterase 1 [ORDO Gene]
- ectonucleotide pyrophosphatase/phosphodiesterase 1 [HGNC gene]
OMIM relation
- Ectonucleotide pyrophosphatase/phosphodiesterase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ENPP1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ENPP1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Nicotinate and Nicotinamide Metabolism Pathway [NCIt concept]
- Pantothenate and CoA Biosynthesis Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
- Riboflavin Metabolism Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
is_target
- ENPP1 Inhibitor RBS2418 [NCIt concept]
- ENPP1 Inhibitor SR-8541A [NCIt concept]

Keyword's position in hierarchy(ies) :

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