Fatty Acid Synthase

Preferred Label : Fatty Acid Synthase;

NCIt synonyms : FASN; EC 2.3.1.85; FAS; Type I Fatty Acid Synthase;

NCIt definition : Fatty acid synthase (2511 aa, 273 kDa) is encoded by the human FASN gene. This protein is involved in long-chain fatty acid synthesis.;

NCIt note : Fatty acid synthase has 7 different enzymatic activities and an acyl carrier domain. The catalytic activities are [acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38), [acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39), 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41), 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100), 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10) and oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14). (UniProt);

Details

Origin ID

C16574;

UMLS CUI

C1871899;

Automatic exact mappings (from CISMeF team)
- 6-phospho-beta-galactosidase [MeSH Supplementary Concept]
- FAS [WHO-ART Included Term]
- FASN protein, human [MeSH Supplementary Concept]
- Fas cell surface death receptor [OMIM gene]
- Fas cell surface death receptor [ORDO Gene]
- Fatty acid synthase [OMIM gene]
- Fetal alcohol syndrome [ORDO Disease]
- fatty acid synthase [HGNC gene]
- fatty acid synthase, type I [MeSH Descriptor]
- fatty acid synthase, type I [MeSH concept]
- fatty acid synthase, type II [MeSH Descriptor]
- fatty acid synthases [MeSH Descriptor]
- fatty acid synthases [MeSH concept]
- fetal alcohol spectrum disorders [MedlinePlus Topic]
- fetal alcohol syndrome [MeSH concept]
Currated CISMeF NLP mapping
- Fatty-acid synthase (substance) [SNOMED CT concept]
- fatty-acid synthase [SNOMED Notion]
OMIM relation
- Fatty acid synthase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FASN protein, human [MeSH Supplementary Concept]
- FASN protein, human [MeSH concept]
- Fatty-acid synthase (substance) [SNOMED CT concept]
- fatty acid synthases [MeSH Descriptor]
- fatty-acid synthase [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- FASN Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Lyase Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Fatty Acid Biosynthesis Pathway [NCIt concept]
- Fatty Acid Elongation Pathway in Mitochondria [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Fatty Acid Metabolism [NCIt concept]
- Hydrolysis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Denifanstat [NCIt concept]

Keyword's position in hierarchy(ies) :

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