Preferred Label : WRN Inhibitor RO7589831;
NCIt synonyms : WRN Inhibitor RG6457; WRN Covalent Inhibitor RO7589831;
NCIt definition : An orally bioavailable and small molecule inhibitor of Werner syndrome ATP-dependent
helicase (WRN; RecQ protein-like 2; Werner syndrome protein), with potential antineoplastic
activity. Upon oral administration, WRN inhibitor RO7589831 covalently binds to and
inhibits the activity of WRN. This may inhibit the growth of cancers with high microsatellite
instability (MSI-H). WRN, a multifunctional enzyme with helicase, ATPase, and exonuclease
activities, plays an important role in maintaining genome stability. Its helicase
activity is essential for the survival of certain cancers with genomic microsatellite
instability associated with defective DNA mismatch repair.;
Molecule name : RO-7589831; RG 6457; RG-6457; RO 7589831;
NCI Metathesaurus CUI : CL1926588;
Origin ID : C204483;
UMLS CUI : C5908052;
Semantic type(s)
- concept_is_in_subset
- has_target
