PARP1 Inhibitor AZD9574

Preferred Label : PARP1 Inhibitor AZD9574;

NCIt synonyms : 6-Fluoro-5-[4-[(5-Fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide; PARP Inhibitor TQB3823;

NCIt definition : An orally bioavailable central nervous system (CNS) penetrant and inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, with potential antineoplastic activity. Upon oral administration, PARP1 inhibitor AZD9574 selectively binds to PARP1, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. AZD9574 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks and double-strand break (DSBs). AZD9574 is able to penetrate the blood-brain barrier (BBB).;

CAS number : 2756333-39-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2756333-39-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD 9574; AZD-9574;

NCI Metathesaurus CUI : CL1793069;

Details

Origin ID

C188237;

UMLS CUI

C5706468;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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