Talazoparib - CISMeF

Preferred Label : Talazoparib;

NCIt definition : An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.;

UNII : 9QHX048FRV;

InChIKey : HWGQMRYQVZSGDQ-HZPDHXFCSA-N;

CAS number : 1207456-01-6;

Molecule name : BMN-673; BMN 673;

Codes from synonyms : 476;

Details

Origin ID

C95733;

UMLS CUI

C4042960;

Automatic exact mappings (from CISMeF team)
- talazoparib [ATC Code]
Currated CISMeF NLP mapping
- Talazoparib [ICD-11 Extension code]
- Talazoparib [SMS substance]
- Talazoparib (substance) [SNOMED CT concept]
- talazoparib [MeSH concept]
- talazoparib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing talazoparib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing talazoparib (medicinal product) [SNOMED CT concept]
- Talazoparib (substance) [SNOMED CT concept]
- talazoparib [MeSH Supplementary Concept]
- talazoparib [ATC Code]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Talazoparib Tosylate [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Talazoparib Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Talazoparib Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients