Talazoparib Tosylate

Preferred Label : Talazoparib Tosylate;

NCIt definition : The tosylate salt form of talazoparib, an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Upon administration, talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.;

UNII : 02WK9U5NZC;

InChIKey : QUQKKHBYEFLEHK-QNBGGDODSA-N;

CAS number : 1373431-65-2;

Drug name : Talzenna;

NCI Metathesaurus CUI : CL553698;

Details

Origin ID

C152494;

UMLS CUI

C4726799;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Talazoparib tosylate (substance) [SNOMED CT concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Talazoparib [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Enzalutamide/Talazoparib Regimen [NCIt concept]
is_salt_form_of
- Talazoparib [NCIt concept]

Keyword's position in hierarchy(ies) :

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