Preferred Label : Basroparib;
NCIt synonyms : Tankyrase Inhibitor STP1002;
NCIt definition : An orally bioavailable inhibitor of the poly (ADP-ribose) polymerase (PARP) enzyme
tankyrase, with potential antineoplastic activity. Upon administration, basroparib
selectively binds to and inhibits the activity of tankyrase. This may block the tankyrase-mediated
poly(ADP-ribosyl)ation of multiple target proteins including various tumor suppressors.
This may include the blockage of the poly(ADP-ribosyl)ation and destabilization of
AXIN, a negative regulator of beta-catenin, and prevents Wnt/beta-catenin signaling.
This may inhibit the activation of transcription of a wide range of target genes of
Wnt/beta-catenin signaling, thereby preventing gene expression of many Wnt-related,
pro-survival proteins and suppressing tumor cell growth. Tankyrase, a member of the
PARP family, plays an important role in the regulation of the Wnt/beta-catenin signaling
pathway, tumor suppressors, as well as telomere maintenance and mitosis regulation.;
UNII : P5LYN8CD74;
CAS number : 1858179-75-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1858179-75-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : STP 1002; STP-1002;
NCI Metathesaurus CUI : CL1407962;
Origin ID : C174060;
UMLS CUI : C5418065;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_target
