NCIt definition : An orally bioavailable, small molecule inhibitor of the nuclear enzymes poly (ADP-ribose)
polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon oral administration,
PARP 1/2 inhibitor TQB3823 selectively binds to and inhibits PARP-1 and -2, thereby
preventing PARP-1 and -2-mediated DNA repair. This promotes genetic instability and
enhances the accumulation of single and double strand DNA breaks, ultimately leading
to apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation
of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.;
Semantic type(s)