Preferred Label : Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent;
NCIt synonyms : Olaparib-BODIPY FL; Fluorescent PARPi Binding Imaging Agent PARPi-FL; PARPi-FL; BODIPY-modified Olaparib Fluorescent Imaging Agent; AZD2281-BODIPY FL; Fluorescent PARP1 Inhibitor PARPi-FL; Boron, (4-((3-((4-(3-(5-((3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)methyl)-1H-pyrrol-2-yl-kappaN)-1-oxopropyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-1(2H)-phthalazinonato)difluoro-,
(T-4)-;
NCIt definition : A poly (ADP-ribose) polymerase type 1 (PARP1) fluorescence imaging agent based on
the PARP1 inhibitor olaparib, in which the cyclopropane group of olaparib is replaced
by the green fluorescent dye boron-dipyrromethene (BODIPY) fluorophore (FL), with
potential fluorescent imaging activity. Upon administration of the fluorescent PARP1
inhibitor PARPi-FL, the olaparib binding moiety specifically targets and binds to
PARP1, which is often overexpressed on cancer cells. Upon fluorescent imaging, the
PARP1-expressing cancer cells can be visualized. PARP1, the nuclear enzyme that catalyzes
post-translational ADP-ribosylation of nuclear proteins, is activated by single-strand
(SS) DNA breaks and overexpressed in certain tumor cells; it plays a key role in DNA
repair, tumor cell resistance and survival.;
UNII : ZMX54372EH;
CAS number : 1380359-84-1;
Molecule name : ABY-029;
NCI Metathesaurus CUI : CL519696;
Origin ID : C133717;
UMLS CUI : C4524845;
Semantic type(s)
- concept_is_in_subset
- has_target
