Preferred Label : Carbon C 14 Fluzoparib;
NCIt synonyms : 14C-Fluzoparib; [14C]-Fluzoparib;
NCIt definition : An orally bioavailable radioconjugate composed of fluzoparib, an orally bioavailable
inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2, radiolabeled with
the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic
profile of fluzoparib. Upon administration of carbon C 14 fluzoparib, fluzoparib targets,
binds to and inhibits PARP, which results in the inhibition of tumor cell proliferation
and survival. Labeling of fluzoparib with the radioactive tracer carbon C 14 allows
for the evaluation of fluzoparib's pharmacokinetic profile, including its absorption,
distribution, metabolism and excretion (ADME).;
NCI Metathesaurus CUI : CL1642791;
Origin ID : C176956;
UMLS CUI : C5447515;
Semantic type(s)
- concept_is_in_subset
- has_target
