Preferred Label : PARP1 Inhibitor HRS-1167;
NCIt definition : An orally bioavailable inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP)
1, with potential antineoplastic activity. Upon oral administration, PARP1 inhibitor
HRS-1167 selectively targets, binds to and inhibits the activity of PARP1, thereby
preventing the repair of damaged DNA via the base excision repair (BER) pathway. This
enhances the accumulation of DNA strand breaks and promotes genomic instability eventually
leading to apoptosis. PARP1 catalyzes post-translational ADP-ribosylation of nuclear
proteins that signal and recruit other proteins to repair damaged DNA and plays a
key role in the repair of single strand DNA (ssDNA) breaks and double-strand breaks
(DSBs).;
Molecule name : HRS 1167; HRS-1167;
NCI Metathesaurus CUI : CL1928606;
Origin ID : C206274;
chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_target
