NCIt definition : An orally bioavailable inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase
(PARP) 1 and 2, with potential antineoplastic activity. Upon administration, venadaparib
selectively binds to PARP-1 and -2 and prevents PARP-1 and -2 mediated DNA repair
of single-strand DNA (ssDNA) breaks via the base-excision repair pathway. This promotes
the conversion of ssDNA breaks to double-stranded DNA breaks, promotes genomic instability
and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation
of nuclear proteins that signal and recruit other proteins to repair damaged DNA and
is activated by ssDNA breaks.;
UNII : PUP792O0IW;
InChIKey : YNBQAYKYNYRCCA-UHFFFAOYSA-N;
CAS number : 1681017-83-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1681017-83-3
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Semantic type(s)