" /> Venadaparib - CISMeF





Preferred Label : Venadaparib;

NCIt definition : An orally bioavailable inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, venadaparib selectively binds to PARP-1 and -2 and prevents PARP-1 and -2 mediated DNA repair of single-strand DNA (ssDNA) breaks via the base-excision repair pathway. This promotes the conversion of ssDNA breaks to double-stranded DNA breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by ssDNA breaks.;

UNII : PUP792O0IW;

InChIKey : YNBQAYKYNYRCCA-UHFFFAOYSA-N;

CAS number : 1681017-83-3;

Molecule name : IDX 1197; IDX-1197;

NCI Metathesaurus CUI : CL1413030;

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30/07/2025


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