Preferred Label : Niraparib Tosylate Monohydrate;
NCIt synonyms : 2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-, 4-Methylbenzenesulfonate,
Hydrate (1:1:1);
NCIt definition : An orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of
poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic
activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1
and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation
of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The
PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins
and is activated by single-strand DNA (ssDNA) breaks.;
UNII : 195Q483UZD;
InChIKey : ACNPUCQQZDAPJH-FMOMHUKBSA-N;
CAS number : 1613220-15-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1613220-15-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Zejula;
NCI Metathesaurus CUI : CL520459;
Origin ID : C133238;
UMLS CUI : C4524505;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
https://www.has-sante.fr/jcms/p_3243403/fr/zejula
2021
false
false
false
France
treatment outcome
insurance, health, reimbursement
Niraparib Tosylate Monohydrate
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
niraparib
administration, oral
adult
Carcinoma, Ovarian Epithelial
fallopian tube neoplasms
peritoneal neoplasms
Fallopian Tube Carcinoma
Peritoneal carcinoma
evaluation of the transparency committee
indazoles
piperidines
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