" /> Niraparib - CISMeF





Preferred Label : Niraparib;

NCIt synonyms : PARP Inhibitor MK4827;

NCIt definition : An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.;

UNII : HMC2H89N35;

InChIKey : PCHKPVIQAHNQLW-CQSZACIVSA-N;

CAS number : 1038915-60-4;

Molecule name : MK-4827; MK 4827;

Codes from synonyms : 356;

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08/05/2025


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