Niraparib - CISMeF

Preferred Label : Niraparib;

NCIt synonyms : PARP Inhibitor MK4827;

NCIt definition : An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.;

UNII : HMC2H89N35;

InChIKey : PCHKPVIQAHNQLW-CQSZACIVSA-N;

CAS number : 1038915-60-4;

Molecule name : MK-4827; MK 4827;

Codes from synonyms : 356;

Details

Origin ID

C80059;

UMLS CUI

C2744440;

Automatic exact mappings (from CISMeF team)
- niraparib [ATC Code]
Currated CISMeF NLP mapping
- Niraparib [ICD-11 More detail]
- Niraparib [LOINC component]
- Niraparib [SMS substance]
- Niraparib (substance) [SNOMED CT concept]
- niraparib [MeSH concept]
- niraparib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing niraparib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Niraparib [LOINC component]
- Niraparib (substance) [SNOMED CT concept]
- Product containing niraparib (medicinal product) [SNOMED CT concept]
- niraparib [MeSH concept]
- niraparib [MeSH Supplementary Concept]
- niraparib [ATC Code]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Niraparib Tosylate Monohydrate [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]
is_free_acid_or_base_form_of
- Niraparib Tosylate Monohydrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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