NCIt definition : An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and
2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds
to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated
DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability
and resulting in apoptosis. The PARP family of proteins catalyzes post-translational
ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA)
breaks.;
UNII : HMC2H89N35;
InChIKey : PCHKPVIQAHNQLW-CQSZACIVSA-N;
CAS number : 1038915-60-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1038915-60-4
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