Preferred Label : PARP7 Inhibitor BY101921;
NCIt definition : An orally available inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP)
7, with potential immunomodulating and antineoplastic activities. Upon oral administration,
PARP7 inhibitor BY101921 targets, binds to, and inhibits the activity of PARP7, which
restores type I interferon (IFN) signaling. This may lead to the induction of both
innate and adaptive immune responses, and the inhibition of tumor growth and proliferation.
PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal
and recruit other proteins to repair damaged DNA.;
Molecule name : BY 101921; BY-101921;
Origin ID : C216092;
chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_target
