Poly (ADP-Ribose) Polymerase Inhibitor

Preferred Label : Poly (ADP-Ribose) Polymerase Inhibitor;

NCIt synonyms : Poly ADP-Ribose Polymerase Inhibitor; Poly(ADP-Ribose) Polymerase Inhibitor;

NCIt related terms : PARP inhibitor;

NCIt definition : Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death.;

Alternative definition : NCI-GLOSS: A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. It may cause cancer cells to die. It is a type of targeted therapy.;

ChEBI ID : CHEBI:62913;

Codes from synonyms : CDR0000660869; CDR0000658053;

Details

Origin ID

C62554;

UMLS CUI

C1882413;

Currated CISMeF NLP mapping
- Poly(ADP-ribose) Polymerase Inhibitors [MeSH Descriptor]
- Poly(ADP-ribose) Polymerase Inhibitors [MeSH concept]
- Substance with nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor mechanism of action (substance) [SNOMED CT concept]
Manual BTNT mappings - CISMeF
- Poly (ADP-ribose) polymerase (PARP) inhibitors [ATC Code]
See also inter- (CISMeF)
- Product containing nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor (product) [SNOMED CT concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Poly (ADP-ribose) polymerase (PARP) inhibitors [ATC Code]
- Poly(ADP-ribose) Polymerase Inhibitors [MeSH Descriptor]
- Product containing nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor (product) [SNOMED CT concept]
- Substance with nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor mechanism of action (substance) [SNOMED CT concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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