" /> PARP Inhibitor CEP-9722 - CISMeF





Preferred Label : PARP Inhibitor CEP-9722;

NCIt related terms : CEP-9722;

NCIt definition : A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA.;

UNII : B68083E4YG;

CAS number : 916574-83-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 916574-83-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CEP-9722;

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29/05/2024


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