PARP Inhibitor CEP-9722

Preferred Label : PARP Inhibitor CEP-9722;

NCIt related terms : CEP-9722;

NCIt definition : A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA.;

UNII : B68083E4YG;

CAS number : 916574-83-9;

Molecule name : CEP-9722;

Détails

Origin ID

C84880;

UMLS CUI

C2827554;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CEP-9722 [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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