NCIt definition : An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase
(PARP) with potential antineoplastic activity. Upon administration, PARP inhibitor
NMS-03305293 selectively binds to PARP and prevents PARP-mediated DNA repair of single-strand
DNA breaks via the base-excision repair pathway. This enhances the accumulation of
DNA strand breaks and promotes genomic instability and eventually leads to apoptosis.
PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal
and recruit other proteins to repair damaged DNA and is activated by single-strand
DNA breaks.;
Semantic type(s)