INO-1001 - CISMeF

Preferred Label : INO-1001;

NCIt definition : A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB).;

UNII : 55E08EN074;

CAS number : 624747-02-0;

Molecule name : INO 1001;

Details

Origin ID

C61315;

UMLS CUI

C1504945;

Currated CISMeF NLP mapping
- INO 1001 [MeSH concept]
- INO 1001 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- INO 1001 [MeSH concept]
- INO 1001 [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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