" /> Saruparib - CISMeF





Preferred Label : Saruparib;

NCIt synonyms : PARP Inhibitor AZD5305;

NCIt definition : An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, saruparib selectively targets and binds to PARP and prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. This may enhance the cytotoxicity of DNA-damaging agents. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. The PARP-mediated repair pathway is dysregulated in a variety of cancer cell types.;

UNII : 16MZ1V3RBT;

CAS number : 2589531-76-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2589531-76-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD 5305; AZD-5305;

NCI Metathesaurus CUI : CL1642566;

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15/05/2024


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