Preferred Label : Fluorine F 18 PARP Inhibitor;
NCIt synonyms : Fluorine F 18 PARPi; [18F]PARPi Imaging Agent; 18F-1(2H)phthalazinone-based PARPi Imaging Agent; [18F]PARPi; 18F Fluorinated PARP1-targeted Probe; [18F]PARP1-targeted Probe; 18F-radiolabeled 1(2H)phthalazinone PARPi; Fluorine F 18 Poly(ADP-ribose) Polymerase Inhibitor;
NCIt definition : A radiotracer consisting of a 1(2H)phthalazinone-based poly(ADP-ribose) polymerase
1 (PARP1) inhibitor (PARPi) radiolabeled with the positron emitting isotope fluorine
F 18, which can potentially be used for the imaging of PARP1 expression using positron
emission tomography (PET). Upon administration, fluorine F 18 PARPi targets and binds
to PARP1. Upon PET, PARP1-expressing tumor cells can be visualized. PARP1, which is
overexpressed in many cancer cell types, catalyzes post-translational ADP-ribosylation
of nuclear proteins and plays a key role in the repair of DNA strand breaks.;
NCI Metathesaurus CUI : CL555925;
Origin ID : C155292;
UMLS CUI : C4733636;
Semantic type(s)
- concept_is_in_subset
- has_target
