Preferred Label : Carbon C 11 AZ14193391;
NCIt synonyms : [11C]AZ14193391; 11C-AZ14193391;
NCIt definition : A radioconjugate composed of AZ14193391, a central nervous system (CNS) penetrant
and selective inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, labeled
with the positron-emitting isotope carbon C 11, with potential use in imaging via
positron emission tomography (PET). Upon administration, carbon C 11 AZ14193391 specifically
targets and binds to PARP1. Upon PET imaging, this radioligand may allow for the assessment
of PARP1 expression in tumors and visualization of AZ14193391. PARP1 catalyzes post-translational
ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair
damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks
and double-strand breaks (DSBs).;
NCI Metathesaurus CUI : CL1927445;
Origin ID : C204973;
concept_is_in_subset
- has_target
