NCIt definition : An orally bioavailable inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP)
1, with potential antineoplastic activity. Upon oral administration, PARP1 inhibitor
HS-10502 selectively binds to and blocks the activity of PARP1, thereby preventing
repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances
the accumulation of DNA strand breaks and promotes genomic instability eventually
leading to apoptosis. HS-10502 may enhance the cytotoxicity of DNA-damaging agents
and reverse tumor cell chemo- and radioresistance. PARP1 catalyzes post-translational
ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair
damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks
and double-strand break (DSBs).;
Semantic type(s)