Simmiparib - CISMeF

Preferred Label : Simmiparib;

NCIt definition : An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1 (PARP1) and 2 (PARP2), with potential antineoplastic activity. Upon oral administration, simmiparib selectively binds to PARP and prevents PARP-mediated DNA repair of breaks in single-stranded DNA via the base excision repair pathway. This induces the accumulation of DNA strand breaks, promotes genomic instability, induces G2/M arrest and leads to apoptosis. PARP is activated by single-strand DNA breaks and catalyzes post-translational ADP-ribosylation of nuclear proteins, which signal and recruit other proteins to repair damaged DNA.;

Molecule name : SMOCL-9112;

NCI Metathesaurus CUI : CL538617;

Détails

Origin ID

C140553;

UMLS CUI

C4508613;

Automatic exact mappings (from CISMeF team)
- simmiparib [MeSH concept]
Currated CISMeF NLP mapping
- simmiparib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- simmiparib [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Poly [ADP-Ribose] Polymerase 2 [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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