Basic Helix-Loop-Helix ARNT-Like Protein 2

Preferred Label : Basic Helix-Loop-Helix ARNT-Like Protein 2;

NCIt synonyms : Basic-Helix-Loop-Helix-PAS Protein MOP9; CYCLE-Like Factor; Class E Basic Helix-Loop-Helix Protein 6; bHLHe6; PAS Domain-Containing Protein 9; Transcription Factor BMAL2; Member of PAS Protein 9; Brain and Muscle ARNT-Like 2; CLIF; Brain and Muscle ARNT-Like Protein 2; ARNTL2; Member of PAS Superfamily 9; BMAL2; Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 2;

NCIt definition : Basic helix-loop-helix ARNT-like protein 2 (636 aa, 71 kDa) is encoded by the human BMAL2 gene. This protein plays a role in the transcriptional activation of genes involved in circadian rhythms.;

NCIt note : Aryl hydrocarbon receptor nuclear translocator-like protein 2 forms a heterodimer with circadian locomoter output cycles protein; the heterodimer can bind to E-box enhancer elements (5'-CACGTG-3'). The interaction of the heterodimeric complex with cryptochrome or period family transcriptional repressors inhibits the ability of the heterodimer to activate gene transcription. (UniProt);

Details

Origin ID

C119697;

UMLS CUI

C1309562;

Automatic exact mappings (from CISMeF team)
- ARNTL transcription factors [MeSH Descriptor]
- Aryl hydrocarbon receptor nuclear translocator-like protein 2 [OMIM gene]
- aryl hydrocarbon receptor nuclear translocator-like 2 protein [MeSH concept]
OMIM relation
- Aryl hydrocarbon receptor nuclear translocator-like protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BMAL2 protein, human [MeSH Supplementary Concept]
- BMAL2 protein, human [MeSH concept]
gene_encodes_gene_product
- BMAL2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Biological Rhythm [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients