Endothelial PAS Domain-Containing Protein 1

Preferred Label : Endothelial PAS Domain-Containing Protein 1;

NCIt synonyms : HIF-2-Alpha; Hypoxia-Inducible Factor 2 Alpha; Class E Basic Helix-Loop-Helix Protein 73; HIF-1alpha-Like Factor; HIF-1-Alpha-Like Factor; EPAS-1; bHLHe73; PAS Domain-Containing Protein 2; HIF2-Alpha; HLF; HIF-1 Alpha-Like Factor; Member of PAS Protein 2; Hypoxia-Inducible Factor 2-Alpha; Basic-Helix-Loop-Helix-PAS Protein MOP2; EPAS1;

NCIt definition : Endothelial PAS domain-containing protein 1 (870 aa, 96 kDa) is encoded by the human EPAS1 gene. This protein plays a role in both the response to hypoxia and transcriptional regulation.;

NCIt note : Endothelial PAS domain-containing protein 1 binds to the DNA sequence 5'-[AG]CGTG-3' found within the hypoxia response element (HRE). (UniProt);

Details

Origin ID

C104306;

UMLS CUI

C1436532;

OMIM relation
- Endothelial pas domain protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EPAS1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EPAS1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelial Cell [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Hypoxia Inducible Factor Family [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-2-Alpha Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Belzutifan [NCIt concept]
- Fluorine F 18 PT2385 [NCIt concept]
- HIF-2alpha Inhibitor [NCIt concept]
- HIF-2alpha Inhibitor AB521 [NCIt concept]
- HIF-2alpha Inhibitor HS-10516 [NCIt concept]
- HIF-2alpha Inhibitor PT2385 [NCIt concept]
- HIF2-alpha Inhibitor NKT2152 [NCIt concept]
- HIF2alpha Inhibitor DFF332 [NCIt concept]
- Zifcasiran [NCIt concept]
- Zifcasiran Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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