Preferred Label : HIF-2alpha Inhibitor HS-10516;
NCIt synonyms : HIF2-alpha Inhibitor HS-10516; HIF-2-alpha Inhibitor HS-10516; HIF2a Inhibitor HS-10516; HIF2alpha Inhibitor HS-10516;
NCIt definition : An orally bioavailable inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential
antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor HS-10516 targets
and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its
subsequent binding to DNA. This results in decreased transcription and expression
of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and
survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor
cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer
cell types, promotes proliferation, progression and metastasis of tumors.;
Molecule name : HS-10516; HS 10516;
NCI Metathesaurus CUI : CL1921207;
Origin ID : C202245;
UMLS CUI : C5907966;
Semantic type(s)
- concept_is_in_subset
- has_target
