Preferred Label : Imdatifan;
NCIt synonyms : HIF2a Inhibitor NKT2152; HIF-2alpha Inhibitor NKT 2152;
NCIt definition : An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential
antineoplastic activity. Upon oral administration, imdatifan targets and binds to
HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding
to DNA. This results in decreased transcription and expression of HIF-2alpha downstream
target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha
reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric
transcription factor overexpressed in many cancer cell types, promotes proliferation,
progression and metastasis of tumors.;
UNII : BL9SLT39J6;
CAS number : 2511247-29-1;
Molecule name : NKT 2152; NKT-2152;
NCI Metathesaurus CUI : CL1922272;
Origin ID : C203107;
UMLS CUI : C5908993;
Semantic type(s)
- concept_is_in_subset
- has_target
