Preferred Label : Fluorine F 18 PT2385;
NCIt synonyms : Fluorine-18 PT2385; 18F-PT2385; [18F]-PT2385; [18F]PT2385;
NCIt definition : A radioconjugate containing PT2385, a small molecule inhibitor of the hypoxia inducible
factor (HIF)-2alpha, conjugated to the positron-emitting isotope fluorine F 18, with
potential imaging activity upon positron emission tomography/computed tomography (PET/CT).
Upon administration of fluorine F 18 PT2385, the PT2385 moiety specifically targets
and binds to HIF-2alpha overexpressed on tumor cells, thereby allowing the visualization
of tumor cells expressing HIF-2alpha upon PET/CT. HIF-2alpha, a heterodimeric transcription
factor overexpressed in many cancer cell types, promotes proliferation, progression
and metastasis of tumors.;
NCI Metathesaurus CUI : CL1772622;
Origin ID : C184310;
UMLS CUI : C5669195;
Semantic type(s)
- concept_is_in_subset
- has_target
