Preferred Label : HIF2alpha Inhibitor DFF332;
NCIt synonyms : HIF-2a Inhibitor DFF332;
NCIt definition : An inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic
activity. Upon administration, HIF-2alpha inhibitor DFF332 targets and binds to HIF-2alpha,
thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA.
This results in decreased transcription and expression of HIF-2alpha downstream target
genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha
reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric
transcription factor overexpressed in many cancer cell types, promotes proliferation,
progression and metastasis of tumors.;
Molecule name : DFF 332; DFF-332;
NCI Metathesaurus CUI : CL1663477;
Origin ID : C180826;
UMLS CUI : C5556650;
Semantic type(s)
- concept_is_in_subset
- has_target
