NCIt definition : An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with
potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes
mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition
of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key
role in proliferation, progression and metastasis of tumors.;
Semantic type(s)