NCIt definition : The sodium salt form of zifcasiran, an RNA interference (RNAi) targeting hypoxia-inducible
factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration,
zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production
of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed
in certain cell types, plays a key role in proliferation, progression and metastasis
of tumors.;
Semantic type(s)