" /> Belzutifan - CISMeF





Preferred Label : Belzutifan;

NCIt synonyms : HIF-2alpha Inhibitor PT2977;

NCIt definition : An orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha (HIF-2a), with potential antineoplastic activity. Upon oral administration, belzutifan binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis.;

UNII : 7K28NB895L;

InChIKey : LOMMPXLFBTZENJ-ZACQAIPSSA-N;

CAS number : 1672668-24-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1672668-24-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Welireg;

Molecule name : PT2977; MK-6482; MK 6482;

NCI Metathesaurus CUI : CL522982;

Codes from synonyms : 29688;

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15/05/2024


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