Transcription Factor E3

Preferred Label : Transcription Factor E3;

NCIt synonyms : Transcription Factor For Immunoglobulin Heavy-Chain Enhancer 3; TFE3; Transcription Factor for IgH Enhancer; bHLHe33; Class E Basic Helix-Loop-Helix Protein 33; Transcription Factor Binding to IGHM Enhancer 3; Transcription Factor-E3; Transcription Factor E Family, Member A;

NCIt definition : Transcription factor E3 (575 aa, 62 kDa) is encoded by the human TFE3 gene. This protein plays a role in both immunity and transcriptional regulation.;

NCIt note : Transcription factor E3 recognizes and binds E-box sequences (3'-CANNTG-5') and binds to the Ig heavy-chain enchancer MUE3 motif and to the USF/MLTF site. Efficient DNA binding requires dimerization with another bHLH protein. (UniProt);

Details

Origin ID

C30094;

UMLS CUI

C0145464;

OMIM relation
- Transcription factor for immunoglobulin heavy-chain enhancer 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TFE3 protein, human [MeSH concept]
- TFE3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TFE3 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- E2F Transcription Factor Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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