Transcription Factor HES-2

Preferred Label : Transcription Factor HES-2;

NCIt synonyms : Hairy and Enhancer of Split 2; HES-2; HES2; bHLHb40; Class B Basic Helix-Loop-Helix Protein 40;

NCIt definition : Transcription factor HES-2 (173 aa, 18 kDa) is encoded by the human HES2 gene. This protein is involved in the repression of transcription.;

NCIt note : Transcription factor HES-2 binds to DNA on N-box motifs: 5'-CACNAG-3'. (UniProt); The transcriptional repression activity of transcription factor HES-2 requires formation of a complex with a corepressor protein of the Groucho/TLE family. (UniProt);

Details

Origin ID

C114519;

UMLS CUI

C1531377;

Automatic exact mappings (from CISMeF team)
- Hes family bhlh transcription factor 2 [OMIM gene]
OMIM relation
- Hes family bhlh transcription factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HES2 protein, human [MeSH Supplementary Concept]
- HES2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HES2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- BHLH Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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