Aryl Hydrocarbon Receptor Nuclear Translocator 2

Preferred Label : Aryl Hydrocarbon Receptor Nuclear Translocator 2;

NCIt synonyms : ARNT Protein 2; ARNT2; KIAA0307; Aryl-Hydrocarbon Receptor Nuclear Translocator 2; Aryl Hydrocarbon Receptor Nuclear Translocator-2; bHLHe1; Class E Basic Helix-Loop-Helix Protein 1;

NCIt definition : Aryl hydrocarbon receptor nuclear translocator 2 (717 aa, 79 kDa) is encoded by the human ARNT2 gene. This protein is involved in DNA binding, transcriptional regulation and xenobiotic metabolism.;

NCIt note : Aryl hydrocarbon receptor nuclear translocator 2 specifically recognizes the xenobiotic response element (XRE), but efficient DNA binding requires dimerization with another bHLH protein. (UniProt);

Details

Origin ID

C28715;

UMLS CUI

C1332336;

OMIM relation
- Aryl hydrocarbon receptor nuclear translocator 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- ARNT2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- BHLH Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Hypoxia Inducible Factor Family [NCIt concept]
- Ligand Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Renal Cell Carcinoma Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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