NCIt synonyms : JPH2; JP2NT; Junctophilin-2 N-Terminal Fragment Chain;
NCIt definition : Junctophilin-2 N-terminal fragment (572 aa, 61 kDa) is encoded by the human JPH2
gene. This protein plays a role in transcription repression of target genes implicated
in cell growth and differentiation, hypertrophy, inflammation and fibrosis during
cardiac stress.;
NCIt note : The junctophilin-2 protein is cleaved by calpain in response to cardiac stress and
leads to the release of the junctophilin-2 N-terminal fragment (JP2NT). This truncated
form has a bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich;
ARR) regions, which are involved in DNA binding and transcriptional repression. (UniProt);