" /> Junctophilin-2 N-Terminal Fragment - CISMeF





Preferred Label : Junctophilin-2 N-Terminal Fragment;

NCIt synonyms : JPH2; JP2NT; Junctophilin-2 N-Terminal Fragment Chain;

NCIt definition : Junctophilin-2 N-terminal fragment (572 aa, 61 kDa) is encoded by the human JPH2 gene. This protein plays a role in transcription repression of target genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis during cardiac stress.;

NCIt note : The junctophilin-2 protein is cleaved by calpain in response to cardiac stress and leads to the release of the junctophilin-2 N-terminal fragment (JP2NT). This truncated form has a bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions, which are involved in DNA binding and transcriptional repression. (UniProt);

NCI Metathesaurus CUI : CL1920719;

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30/07/2025


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