" /> Homeobox Protein CDX-2 - CISMeF





Preferred Label : Homeobox Protein CDX-2;

NCIt synonyms : CDX-3; Homeobox Protein CDX2; CDX2 Protein; Insulin-Regulating Transcription Factor CDX3; Caudal-Type Homeo Box Transcription Factor 3; CDX2; Caudal Type Homeobox Transcription Factor 2; Caudal-Type Homeobox Protein 2; CDX3; Caudal-Type Homeo Box Transcription Factor 2; Caudal Type Homeobox Transcription Factor-2;

NCIt definition : Homeobox protein CDX-2 (313 aa, 34 kDa) is encoded by the human CDX2 gene. This protein is involved in transcription and intestinal morphogenesis.;

NCIt note : Caudal Type Homeo Box Transcription Factor 2, encoded by the human CDX2 gene, is a homeodomain protein. This nuclear protein is involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM);

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18/05/2024


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